Advancing
biological
therapies

Project funded by the Axencia Galega de Innovación and co-financed by the European Union under the Programa Galicia FEDER 2021–2027

USC

Advancing biological therapies through integrated preclinical development.

UMBIO is the USC-SunRock Joint Research Unit for the pleclinical development of biological therapies, a public-private collaboration between Universidade de Santiago de Compostela (USC) and SunRock Biopharma that brings together academic research, advanced scientific capabilities and biotech expertise to accelerate the development and validation of new therapeutic candidates in oncology and immune-mediated inflammatory diseases.

UMBIO is a project funded by the Galician Innovation Agency (GAIN) and co-funded by the European Union under the Galicia FEDER 2021–2027 Programme (European Regional Development Fund).

Connecting science, technology and industry

UMBIO aims to accelerate the preclinical development of innovative biological therapies by combining scientific knowledge, specialised technologies and industry expertise within a shared research environment. The Joint Research Unit focuses on five main objectives.

Main objectives

Functional charaterisation

Characterisation of new therapeuthic antibodies and investigation of their mechanisms of action to better understand their biological activity and therapeutic potential. 

Pharmacokinetics and biodistribution

Advanced analytical and molecular imaging techniques to study how therapeutic candidates are distributed and behave in vivo. 

Preclinical efficacy

Evaluation of therapeutic activity in relevant preclinical models to generate evidence supporting candidate selection and development decisions. 

Safety assessment

Generation of early safety data to support the progression of selected candidates towards regulatory and clinical stages. 

Therapeutic Antibody Safety Assessment

Assessing therapeutic antibody safety through regulatory toxicology studies in non-human primates to support preclinical development.

Complementary capabilities. One shared Goal

UMBIO brings together the experience of SunRock Biopharma in therapeutic antibody development with the scientific and technological capabilities of the Universidade de Santiago de Compostela. 
The Unit integrates expertise from: 

UMBIO also collaborates with Fundación Kærtor, contributing additional expertise in drug discovery and translational research.

A Focus on innovative biological therapies

UMBIO works on the development of new therapeutic approaches based on monoclonal antibodies and antibody-drug conjugates (ADCs).

Its activity is particularly focused on areas with unmet clinical needs in oncology and immune-mediated inflammatory diseases, integrating complementary scientific and technological capabilities to advance promising therapeutic candidates.

The Joint Research Unit also contributes to the development of SunRock Biopharma programmes targeting areas such as CCR9 and HER3.

Imagen de un laboratorio

UMBIO at a glance

UMBIO brings together the experience of SunRock Biopharma in therapeutic antibody development with the scientific and technological capabilities of the Universidade de Santiago de Compostela.

€2.73million

Total project budget

30 months

From March 2026 to September 2028

2 organisations

Universidade de Santiago de Compostela + SunRock Biopharma

4 areas of development

Functional characterisation · Pharmacokinetics· Efficacy · Safety 

Project funded by the Axencia Galega de Innovación and co-financed by the European Union under the Programa Galicia FEDER 2021–2027

USC

Research progress

UMBIO will report on the main scientific and technological advances achieved throughout the development of the Joint Research Unit. 

2026

milestones

2027

milestones

2028

milestones

Building stronger paths from research to therapy 

UMBIO creates a shared environment where scientific knowledge, specialised infrastructures and biotech expertise come together to advance the preclinical development of new biological therapies.

By strengthening the connection between research and industry, UMBIO helps promising biomedical innovation move towards its next stage of development.

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2026 milestones

During the 2026 period (March to September 2026), UMBIO has generated an impact in the scientific-technical sphere, as well as in the creation and stabilization of highly qualified jobs and in the communication and dissemination of its activities.

Scientific and technical progress:

  • Progress has been made in the in vitro analysis of the efficacy of selected antibodies; this included evaluating the cytotoxic activity of selected ADCs and ruling out potential cytotoxicity resulting from the ADC labeling process.
  • A collaboration agreement has been initiated between the Galician Agency for Blood, Organs, and Tissues (ADOS) and CiMUS to obtain immune cells from blood for use in immune-mediated cytotoxicity studies.
  • To validate therapeutic candidates, genetic editing—specifically using the short hairpin RNA (shRNA) technique—has been employed to modulate the expression of the therapeutic target.
  • Conjugation and radiolabeling conditions for the compound have been optimized for in vivo positron emission tomography (PET) imaging studies, achieving highly efficient radiolabeling with minimal levels of free (unbound) radiolabel.
  • The biodistribution of labeled ADCs was evaluated in in vivo mouse studies, confirming the absence of side effects. Distinct biodistribution and elimination profiles were observed for the free antibody versus the conjugated form, suggesting differences in their in vivo behavior and clearance pathways.
  • An in vivo toxicology study in mice is currently underway, involving bioanalytical and histopathological analysis of samples.
  • Development has begun on an immunocompetent syngeneic ovarian cancer model to explore the efficacy of the therapeutic candidates and their interaction with the endogenous immune system.